Hey, I have a question about the eth rune...

Say I socketed a Doombringer with an eth rune. Is it true how there's a bug or glitch that allows minus of ALL defense with ONE hit? Let's say I use my doombringer socketed w/ eth and try to kill pindle. Would that mean ONE HIT gives him 0 defense and gives me 95% chance of hitting him? Plz answer

~thx in advance