Zerg can go up against that quite easy with the use of ol decoy to by pass the turret wall. A drop of hydra/ling and defiler would just destroy the base without much trouble. Swarm protect against hit, plague can make bc/wraith quite useless. Also using 1 or 2 ol decoy + scourge can take down a flying building in no time revealing what is under and creating a great oportunity for the queen to do her stuff.

While against protoss the problem would mainly be how would you stop them from getting in ? Im sure you seen ppl use hallucination on shuttle or arbitrer. There again the wraith and bc are of little use. Psy strom and archon can be quite deadly on them.