All drops lately have been crap everywhere. I think Divinity Coast is the only place im finding things, which are decent runes. I got lucky with two major vigors in one run, sold for 4.5k each. In that one run I also got a major earth and major air rune... so yeah, its a hot spot for me right now... dunno how long.

From what I been told, everytime you load into an area the drops are reduced... so areas that people rarely go to have a better chance of dropping good items. True? Dunno