How will my zerk barb fare?

I think that you will need to wield a shield because without it you will get hit EVERY single time becuase when ever you swing with Zerk you defence goes to 0. With a Botd Zerker your range will be 3. Also zerker barbs have a hard time hitting anything but melee becuase it has a slow animation. Not sure of the rest of your equipment but i think enigma would be the best armor to allow you to get close enough to hit anyone except tele whores.