I think that you will need to wield a shield because without it you will get hit EVERY single time becuase when ever you swing with Zerk you defence goes to 0. With a Botd Zerker your range will be 3. Also zerker barbs have a hard time hitting anything but melee becuase it has a slow animation. Not sure of the rest of your equipment but i think enigma would be the best armor to allow you to get close enough to hit anyone except tele whores.
Think not disdainfully of death, but look on it with favor; for even death is one of the things that Nature wills.