I think I can actually do this with your help, sov.
Just you and me? I can kill Duriel alone, maybe I can kill Lilith alone; i dont see why I cant kill the 3rd guy alone(on my way to getting the eye, brain and the other part i forgot
Izzy is ez, Liltih is a bit harder. Durial I dunno yet. But hes probably ez too. Im going to do it all bymyself, No1 is gettting my charm mofos. They wierd thing is.. they made this easier to get really, then the anni. Anni's if you don't know exactly what your doing, then they more of a chance thing. These all you have to do is put in some work.
This is very do-able all by yourself. Just make sure to stack resists, have some DR and go to town. Its much easier with a smiter though if you don't have a conviction aura around for your sorc or whatever. As on your way some monsters are immune to magic your standard mfing hammerdin may also have some trouble. A Judicator or a V/t should be ok though solo.
You'll more then likely have a hammerdin with you so you'll have concentration. Only thing I'm worried about is resists on a melee character. You get BOMBARDED with elemental shit, an mephisto has conviction.
If you have high resist, open wounds, and prevent monster healing, they should do fine.