Samus vs. ANYBODY

Well, these are D&D books, correct? These two are sorcerers, then, I am to assume.

Considering that they're both obviously high-level characters, I'll assume that they probably don't even need to bother with somatic or material components. Soth revealed, at the very least, that spoken components are needed by him to cast. I can't say the same for Rasitlin, but it doesn't really matter.

Magic, in D&D, at the very least takes time and concentration to use. If Soth still needs to use spoken components, he's already looking at a serious disadvantage because that's a tell-tale. Samus will see it coming a mile away.

Either way, you're looking at spell-casters going up against a highly armored bounty hunter who needs no preparation time for her attacks. The only thing Samus needs time for is scanning her opponent, which only takes a few seconds and completely reveals the capabilities and weaknesses of the scanned opponent. Samus is simply too versatile to be taken out by a mage.