Kain vs. Dante

Well, in a scene, energy bolt bounces off from Dante even when he's in non-devil form, and swords impale him yet he can still walk steadily and pull it out, while the wound heals instantly. (If you take scenes into account, Dante would have no weakness whatsoever.)

A charged up Nightmare Beta is far more deadly than you think. When charged, it can release up to 20 beams and every shot would bounce off the wall and platforms creating more beams.

What I usually love to do is freeze time when a enemy exposes the weakspot, and either charge up nightmare beta, or go near and uses Kick13 continuously.

There's a demon called "Shadow" in DMC, and it has to be one of the most cunning, agile, and deadly enemy I've ever seen... Dante can take on three of those at the same time without take a scratch.

And the fact is Dante can very well react to any teleporting demon. The Despair in DMC2 for example (I forgot the full name) almost abuses teleportation, yet teleport does not mean a sure hit.

In his Alastor Devil Mode... he's pretty much charged with lightning. When in the air, he shoots lightning (not from a gun...), and can charge into the enemy as a Vortex of lightning, and is invulnerable when doing so.

As for agility, Dante has wall hike and air hike, which allows him for a second jump, covering a much further distance.